Bowel Cancer

Experimental study of delivery of humidified-warm carbon dioxide during open abdominal surgery

S Carpinteri, S Sampurno, J Malaterre, R Millen, M Dean, J Kong, T Chittleborough, A Heriot, AC Lynch, RG Ramsay

2018-04-01

Background: The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO<inf>2</inf>) delivered into th..

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer

R Millen, J Malaterre, RS Cross, S Carpinteri, J Desai, B Tran, P Darcy, P Gibbs, O Sieber, N Zeps, P Waring, S Fox, L Pereira, RG Ramsay

2016-07-02

The presence of tumor immune infiltrating cells (TILs), particularly CD8⁺ T-cells, is a robust predictor of outcome in ..

Intestinal-specific activatable Myb initiates colon tumorigenesis in mice

J Malaterre, L Pereira, T Putoczki, R Millen, S Paquet-Fifield, M Germann, J Liu, D Cheasley, S Sampurno, SA Stacker, MG Achen, RL Ward, P Waring, T Mantamadiotis, M Ernst, RG Ramsay

2016-05-12

Transcription factor Myb is overexpressed in most colorectal cancers (CRC). Patients with CRC expressing the highest Myb are more ..

CDK9 inhibitors selectively target estrogen receptor-positive breast cancer cells through combined inhibition of MYB and MCL-1 expression

P Mitra, RM Yang, J Sutton, RG Ramsay, TJ Gonda

2016-01-01

Our previous studies showed that MYB is required for proliferation of, and confers protection against apoptosis on, estrogen recep..

Myb via TGFβ is required for collagen type 1 production and skin integrity

S Sampurno, R Cross, H Pearson, P Kaur, J Malaterre, RG Ramsay

2015-04-01

Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the archi..

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

H Xu, Y Yan, S Deb, D Rangasamy, M Germann, J Malaterre, NC Eder, RL Ward, NJ Hawkins, RW Tothill, L Chen, NJ Mortensen, SB Fox, MJ McKay, RG Ramsay

2014-12-11

Loss of heterozygosity (LOH) of the adenomatous polyposis coli (. APC) gene triggers a series of molecular events leading to intes..

Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

M Germann, H Xu, J Malaterre, S Sampurno, M Huyghe, D Cheasley, S Fre, RG Ramsay

2014-11-01

Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..

Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78

YR Miao, BL Eckhardt, Y Cao, R Pasqualini, P Argani, W Arap, RG Ramsay, RL Anderson

2013-04-15

Purpose: The major cause of morbidity in breast cancer is development of metastatic disease, for which few effective therapies exi..

The CSF-1 receptor fashions the intestinal stem cell niche

D Akcora, D Huynh, S Lightowler, M Germann, S Robine, JR de May, JW Pollard, ER Stanley, J Malaterre, RG Ramsay

2013-03-01

Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small inte..

Myb controls intestinal stem cell genes and self-renewal

D Cheasley, L Pereira, S Lightowler, E Vincan, J Malaterre, RG Ramsay

2011-12-01

Rapid advances have been made in the understanding of how the highly proliferative gastrointestinal tract epithelium is regulated ..